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Showing 1–6 of 6 results
Advanced filters: Author: Alex P. S. Brogan Clear advanced filters

  • Freeze-drying of aqueous myoglobin–polymer surfactant nanoconjugates affords a water-free solid that melts at room temperature to produce a viscous solventless liquid protein that exhibits near-native secondary structure and reversible dioxygen binding. The results challenge the accepted role of solvent molecules in mediating protein structure and function, and offer new opportunities in protein-based nanoscience and bionanotechnology.

    • Adam W. Perriman
    • Alex P. S. Brogan
    • Stephen Mann
    Research
    Nature Chemistry
    Volume: 2, P: 622-626

  • Enzymatic reactions typically occur in aqueous media or with hydrated enzymes. Here, the authors form fluid enzyme-polymer conjugates with sub-solvation levels of water, and demonstrate catalytic hydrolysis in the absence of a solvent at high temperatures.

    • Alex P. S. Brogan
    • Kamendra P. Sharma
    • Stephen Mann
    Research
    Nature Communications
    Volume: 5, P: 1-8

  • As a consequence of high chemical resistance and low solubility in conventional solvents, deconstructing biomass into fuels and other useful chemical building blocks remains a challenge. Now, through enzyme modification and ionic liquid solvents, it is possible to homogeneously biocatalytically convert cellulose to sugars at a rate 30 times greater than is achievable in water.

    • Alex P. S. Brogan
    • Liem Bui-Le
    • Jason P. Hallett
    Research
    Nature Chemistry
    Volume: 10, P: 859-865

  • Tuning protein solubilization in deep eutectic solvents (DESs) is useful for enhancing enzymatic reactions, preserving therapeutic biomolecules, and developing biomaterials, but it has only been demonstrated for a narrow range of anhydrous DESs. Here, using myoglobin as a case study, the authors show that surface modification can be used to solubilize proteins in both hydrophilic and hydrophobic DESs, with polarity and hydrogen bond capacity influencing the protein conformational state.

    • Adrian Sanchez-Fernandez
    • Jake H. Nicholson
    • Alex P. S. Brogan
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-7

  • Ionic liquids are used as solvents in biocatalysis but how they interact with the structures of proteins is imperfectly understood. Here the effect of three common ionic liquids on the structure of green fluorescent protein is studied using a suite of experimental techniques, finding a complex relationship which is poorly captured by any single technique.

    • Liem Bui-Le
    • Coby J. Clarke
    • Jason P. Hallett
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-9