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Showing 1–4 of 4 results
Advanced filters: Author: Alex S Genshaft Clear advanced filters

  • Spatial transcriptomics aims to pair omic data with tissue structure. Here the authors report Spatially PhotoActivatable Colour Encoded Cell Address Tags (SPACECAT) to track and isolate live cells by location; this enables spatially informed downstream assays like scRNA-seq and flow cytometry.

    • Alex S Genshaft
    • Carly G. K. Ziegler
    • Alex K. Shalek
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Existing single-cell RNA-seq methods provide the transcriptome of a cellular phenotype at a single time point. Here, Kimmerlinget al. present a microfluidic platform that enables off-chip single-cell RNA-seq after multigenerational lineage tracking under controlled culture conditions.

    • Robert J. Kimmerling
    • Gregory Lee Szeto
    • Scott R. Manalis
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • As the genetic and phenotypic heterogeneities among cells become more appreciated, there is increasing demand for technologies that facilitate high-throughput and high-efficiency single-cell 'omic' analyses in miniaturized and automated formats. This Review discusses the diverse microfluidic methodologies — with a primary focus on valve-, droplet- and nanowell-based platforms — for characterization of the genomes, epigenomes, transcriptomes and proteomes of single cells, and addresses technical considerations and future opportunities.

    • Sanjay M. Prakadan
    • Alex K. Shalek
    • David A. Weitz
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 345-361