Nature Search

Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Unlocking biomarker discovery: Large scale application of aptamer proteomic technology for early detection of lung cancer

Rachel Ostroff
William Bigbee
Edward Brody
ResearchOpen Access15 Jun 2010
Nature Precedings

P: 1
Publisher Correction: Scaling up dissection of functional RNA elements

Marc Bühler
Alex Charles Tuck
Amendments and Corrections12 Aug 2020
Nature Structural & Molecular Biology

Volume: 27, P: 870
Calfacilitin is a calcium channel modulator essential for initiation of neural plate development

Calcium signalling has been implicated in neural induction in the embryo. The authors identify Calfacilitin as a regulator of CaV1.2 calcium channels, which is required for induction of the pre-neural specifiers Geminin and Sox2 in the early chick embryo.

Costis Papanayotou
Irene De Almeida
Claudio D. Stern
ResearchOpen Access14 May 2013
Nature Communications

Volume: 4, P: 1-11
A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits

The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering the metabolism of the corresponding mRNAs.

Jérôme O. Rouvière
Manuel Bulfoni
Benoit Palancade
ResearchOpen Access25 Apr 2018
Nature Communications

Volume: 9, P: 1-13
Scaling up dissection of functional RNA elements

Translation and mRNA decay are tightly connected processes governing protein production, and their regulation involves an elaborate network of protein factors and sequence elements. A massively parallel RNA-based reporter system now reveals regulatory pathways triggered by 5′ UTR elements and allows dissection of the interplay between translation and mRNA decay.

Marc Bühler
Alex Charles Tuck
News & Views03 Aug 2020
Nature Structural & Molecular Biology

Volume: 27, P: 771-773
Human and mouse essentiality screens as a resource for disease gene discovery

Discovery of causal variants for monogenic disorders has been facilitated by whole exome and genome sequencing, but does not provide a diagnosis for all patients. Here, the authors propose a Full Spectrum of Intolerance to Loss-of-Function (FUSIL) categorization that integrates gene essentiality information to aid disease gene discovery.

Pilar Cacheiro
Violeta Muñoz-Fuentes
Coleen Kane
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Doing well by doing good with the performance of United Nations Global Compact Climate Change Champions

Moses Msiska
Alex Ng
Randall K. Kimmel
ResearchOpen Access10 Dec 2021
Humanities and Social Sciences Communications

Volume: 8, P: 1-11

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