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Showing 1–6 of 6 results
Advanced filters: Author: Alexander Atamian Clear advanced filters

  • A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, showing potential to assess organoid fidelity and facilitate protocol development.

    • Zhisong He
    • Leander Dony
    • Barbara Treutlein
    ResearchOpen Access
    Nature
    Volume: 635, P: 690-698

  • A study integrating single-cell RNA-sequencing and electrophysiology data shows that in mouse, the cellular repertoire of the thalamic reticular nucleus is characterized by a transcriptomic gradient defined at its extremes by mutually exclusive expression of Spp1 and Ecel1, providing insights into the organizational principles underlying the divergent functions of this brain region.

    • Yinqing Li
    • Violeta G. Lopez-Huerta
    • Guoping Feng
    Research
    Nature
    Volume: 583, P: 819-824

  • Multiple methods for deriving human cortical organoids have been established in the past decade. A study now systematically compares patterning strategies and shows that combined WNT and dual SMAD inhibition is superior to dual SMAD inhibition alone in inducing robust cortical identity in 3D human pluripotent stem-cell aggregates.

    • Alexander Atamian
    • Marcella Birtele
    • Giorgia Quadrato
    News & Views
    Nature Cell Biology
    Volume: 24, P: 805-806