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Showing 1–5 of 5 results
Advanced filters: Author: Alexander Bujotzek Clear advanced filters

  • ALL-conformations, a dataset capturing the full range of experimentally observed conformations of CDR loops, T cell and antibody regions interacting with antigen targets, is introduced. ITsFlexible—a deep learning tool trained on this new dataset—advances predictions of immune receptor structural dynamics.

    • Fabian C. Spoendlin
    • Monica L. Fernández-Quintero
    • Charlotte M. Deane
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 1755-1767

  • The use of bispecific antibodies to target tumour-specific epitopes presented by MHC molecules in tumour tissue is a promising avenue for cancer immunotherapy. Here the authors use a mass-spectrometry guided analysis to identify off-target MHC-peptide complexes that bind to TCR-like antibodies next to the target peptide, enabling a novel approach to monitoring of antibody specificity during clinical maturation and development.

    • Estelle Marrer-Berger
    • Annalisa Nicastri
    • Nicola Ternette
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.

    • Steven X. Cho
    • Ina Rudloff
    • Marcel F. Nold
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19

  • ImmuneBuilder is a set of deep learning models trained to predict the structure of antibodies, nanobodies, and T-Cell receptors with state-of-the-art accuracy while being much faster than AlphaFold2 and AlphaFoldMultimer.

    • Brennan Abanades
    • Wing Ki Wong
    • Charlotte M. Deane
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-8

  • Fernández-Quintero et al. employ molecular dynamics simulations in combination with experimental structural information to demonstrate that antibodies exist as several interconverting paratope states. They propose that dynamic conformational transitions on the micro-to-millisecond timescale are responsible for antibody allostery in contrast to the long believed paradigm of static canonical structures determining binding properties and specificity of antibodies.

    • Monica L. Fernández-Quintero
    • Nancy D. Pomarici
    • Klaus R. Liedl
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14