Nature Search

An early pre-liver intraembryonic source of CFU-S in the developing mouse

Alexander L. Medvinsky
Nina L. Samoylina
Elaine A. Dzierzak
Research01 Jul 1993
Nature

Volume: 364, P: 64-67
Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel

The accessory β2 subunit was proposed to inactivate BK channels via the ball-and-chain model, but structural evidence was missing. Here, using cryo-EM, the authors captured the occlusion of the BK channel pore by the N-terminus of the β2 subunit.

Shubhangi Agarwal
Elizabeth D. Kim
Crina M. Nimigean
ResearchOpen Access19 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
The natural selection of good science

Scientists fear that systemic incentives lead to poor science. Stewart and Plotkin use modelling to show how a scientific process emphasizing the use of theory to select hypotheses can allow good science to thrive in the face of pressure to publish.

Alexander J. Stewart
Joshua B. Plotkin
Research17 May 2021
Nature Human Behaviour

Volume: 5, P: 1510-1518
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Co-infection with SARS-CoV-2 Omicron and Delta variants revealed by genomic surveillance

Here, using genomic approaches, Rockett et al. identify Omicron and Delta SARS-CoV-2 co-infections in two adults, highlighting the usefulness of genomic surveillance for the timely recognition of co-infections in situations when different variants of the virus are circulating in the community.

Rebecca J. Rockett
Jenny Draper
Vitali Sintchenko
ResearchOpen Access18 May 2022
Nature Communications

Volume: 13, P: 1-7
Silent synapses dictate cocaine memory destabilization and reconsolidation

Cocaine-generated silent synapses dictate the encoding, consolidation, retrieval-induced destabilization and reconsolidation of cocaine memories, and these syapses can be targeted to reduce drug seeking and relapse.

William J. Wright
Nicholas M. Graziane
Yan Dong
Research02 Dec 2019
Nature Neuroscience

Volume: 23, P: 32-46
TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1

Anna Caliò
Shuko Harada
Guido Martignoni
Research18 Nov 2020
Modern Pathology

Volume: 34, P: 842-850
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus

David Suster
German Pihan
Saul Suster
Research04 Jul 2018
Modern Pathology

Volume: 31, P: 1801-1806
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Heidi M. Harmon
Erik A. Jensen
Elaine Romano
Research04 Feb 2020
Journal of Perinatology

Volume: 40, P: 616-627
Diagnostic utility of one-stop fusion gene panel to detect TFE3/TFEB gene rearrangement and amplification in renal cell carcinomas

Shuko Harada
Anna Caliò
Alexander C. Mackinnon
Research19 Jun 2021
Modern Pathology

Volume: 34, P: 2055-2063
Use of mucolytics and inhaled antibiotics in the NICU

Alexander I. Gipsman
Anita Bhandari
Vineet Bhandari
ReviewsOpen Access19 Nov 2024
Journal of Perinatology

Volume: 45, P: 5-12
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma

Alexander C Mackinnon Jr
Arturo Luevano
Saul Suster
Research03 Jan 2014
Modern Pathology

Volume: 27, P: 1063-1072
Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

Lauren Osborne
Makena Clive
Zachary Kaminsky
Research27 Oct 2015
Neuropsychopharmacology

Volume: 41, P: 1648-1658
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Amendments and Corrections18 May 2020
Molecular Psychiatry

Volume: 26, P: 5465

Search

An early pre-liver intraembryonic source of CFU-S in the developing mouse

Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

The natural selection of good science

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Co-infection with SARS-CoV-2 Omicron and Delta variants revealed by genomic surveillance

Silent synapses dictate cocaine memory destabilization and reconsolidation

TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus

Identification of common genetic risk variants for autism spectrum disorder

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Diagnostic utility of one-stop fusion gene panel to detect TFE3/TFEB gene rearrangement and amplification in renal cell carcinomas

Use of mucolytics and inhaled antibiotics in the NICU

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma

Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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