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Obesity is driven by a build-up of molecular mesh around hunger neurons

The accumulation of a network of proteins and sugars called the extracellular matrix stops insulin from reaching hunger-regulating neurons, disrupting normal food intake and metabolism, and contributing to obesity.

Alexander Dityatev
News & Views18 Sept 2024
Nature

Volume: 633, P: 771-772
The dual role of the extracellular matrix in synaptic plasticity and homeostasis

The extracellular matrix (ECM) plays a key part in diverse cellular processes. Dityatev and colleagues review how the ECM can have opposing effects on neuronal function — promoting plasticity or homeostasis of synaptic contacts — depending on the physiological context and regulation by key proteases.

Alexander Dityatev
Melitta Schachner
Peter Sonderegger
Reviews14 Oct 2010
Nature Reviews Neuroscience

Volume: 11, P: 735-746
Context value updating and multidimensional neuronal encoding in the retrosplenial cortex

Goal-directed behaviors require the brain to integrate information across many task-related dimensions. Here, the authors use a virtual context discrimination paradigm in mice to demonstrate the capacity for neurons in the retrosplenial cortex to exhibit multidimensional encoding across learning.

Weilun Sun
Ilseob Choi
Alexander Dityatev
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder.

Nataliya Gorinski
Monika Bijata
Evgeni Ponimaskin
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-14
Extracellular matrix molecules and synaptic plasticity

Alexander Dityatev
Melitta Schachner
Reviews01 Jun 2003
Nature Reviews Neuroscience

Volume: 4, P: 456-468
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Synapses are surrounded by an extracellular matrix (ECM) of extremely long-lived proteins that is thought to only be remodeled by proteolysis and de novo synthesis. Here, the authors show an alternative molecular recycling mechanism that occurs for the key ECM protein Tenascin-R.

Tal M. Dankovich
Rahul Kaushik
Silvio O. Rizzoli
ResearchOpen Access08 Dec 2021
Nature Communications

Volume: 12, P: 1-23
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

Massimiliano Caiazzo
Maria Teresa Dell’Anno
Vania Broccoli
Research03 Jul 2011
Nature

Volume: 476, P: 224-227
Structure of serotonin receptors: molecular underpinning of receptor activation and modulation

Markus Zweckstetter
Alexander Dityatev
Evgeni Ponimaskin
Research HighlightsOpen Access18 Jun 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-3
Serotonin 5-HT₄ receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin

Schill, Bijata, Kopach et al. show that 5-HT₄R activation leads to maturation of dendritic spines in hippocampal neurons via G13/RhoA signaling. The dendritic changes are complemented with corresponding changes in excitatory transmission, suggesting a role for 5-HT₄R in dendritic spine remodeling.

Yvonne Schill
Monika Bijata
Evgeni Ponimaskin
ResearchOpen Access14 Feb 2020
Communications Biology

Volume: 3, P: 1-16

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