Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–10 of 10 results
Advanced filters: Author: Alexander F. A. Keszei Clear advanced filters

  • Antibody diversification relies on the intentional mutagenesis of immunoglobulin genes for adaptive immune responses. Here, the authors identified a CTLH E3 ubiquitin ligase complex that co-opts FAM72A to recruit and degrade the UNG2 base excision repair factor to permit mutagenesis.

    • Philip Barbulescu
    • Chetan K. Chana
    • Alberto Martin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • tRNA modifications are vital for their function in protein synthesis, one of the most central processes in all living cells. Here the authors show how KEOPS, a multi-subunit tRNA modifying complex, engages and acts on a substrate tRNA.

    • Samara Mishelle Ona Chuquimarca
    • Jonah Beenstock
    • Frank Sicheri
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Through structural analysis of the activation of bacterial STING, the molecular basis of STING filament formation and TIR effector domain activation in antiphage signalling is defined.

    • Benjamin R. Morehouse
    • Matthew C. J. Yip
    • Philip J. Kranzusch
    ResearchOpen Access
    Nature
    Volume: 608, P: 803-807

  • Cryo-EM structures of the cytosolic metazoan GET complex, which targets nascent tail-anchored membrane proteins to the endoplasmic reticulum, reveal interactions that coordinate client transfer between two protein chaperones.

    • Alexander F. A. Keszei
    • Matthew C. J. Yip
    • Sichen Shao
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 1029-1037

  • Structures of prokaryotic homologues of STING permit the reconstruction of the evolutionary trajectory of its incorporation into metazoan innate immunity, and reveal a role for the conserved cGAS–STING pathway in prokaryotic defence against bacteriophages.

    • Benjamin R. Morehouse
    • Apurva A. Govande
    • Philip J. Kranzusch
    Research
    Nature
    Volume: 586, P: 429-433

  • Here, the authors develop a protein engineering method that enables high-resolution structural biology study of human fatty acid synthase. Using this technique, they uncover unique structural features of the enzyme and the mechanism of its inhibition by an anticancer drug Denifanstat.

    • S. M. Naimul Hasan
    • Jennifer W. Lou
    • Mohammad T. Mazhab-Jafari
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • During ribosome-associated quality control (RQC), ANKZF1 severs polypeptidyl-tRNAs on RQC complexes by cleaving the terminal 3′CCA nucleotides, which leads to tRNA fragments that are ‘quality checked’ and recycled in the cytosol.

    • Matthew C. J. Yip
    • Alexander F. A. Keszei
    • Sichen Shao
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 343-349