Nature Search

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Marcus J. Tol
Yuta Shimanaka
Peter Tontonoz
Research27 Jun 2025
Nature Metabolism

Volume: 7, P: 1424-1442
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Hansen et al. compile and share an atlas of neurotransmitter receptor/transporter densities in the human cortex and show that receptor achitecture reflects brain structure, function, dynamics, cognitive specialization and disease vulnerability.

Justine Y. Hansen
Golia Shafiei
Bratislav Misic
ResearchOpen Access27 Oct 2022
Nature Neuroscience

Volume: 25, P: 1569-1581
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Oxidative stress can promote neurodegeneration. Akassoglou and colleagues describe Tox-seq, a functional single-cell RNA sequencing method to identify oxidative stress transcriptional signatures in CNS-resident cells. Tox-seq identified coagulation and glutathione-redox pathway genes that are coupled to oxidative stress and that could be targeted by the glutathione-regulating small molecule acivicin.

Andrew S. Mendiola
Jae Kyu Ryu
Katerina Akassoglou
Research13 Apr 2020
Nature Immunology

Volume: 21, P: 513-524
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization

An adipocyte-selective product of the Clstn3 locus (CLSTN3β) facilitates the use of stored triglyceride by limiting lipid droplet (LD) expansion, defining a molecular mechanism that regulates LD form and function to facilitate lipid utilization in thermogenic adipocytes.

Kevin Qian
Marcus J. Tol
Peter Tontonoz
Research07 Dec 2022
Nature

Volume: 613, P: 160-168
FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance

An online, manually curated and continually updating database of fungal antimicrobial resistance mutations provides a starting point for further research in fungal AMR.

Camille Bédard
Alicia Pageau
Christian R. Landry
Research11 Aug 2025
Nature Microbiology

Volume: 10, P: 2338-2352
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Fibrin deposition occurs after the blood–brain barrier is breached. Akassoglou and colleagues generate a therapeutic monoclonal antibody that targets a cryptic fibrin epitope to suppress activation of innate immune responses in the CNS and diminish neuroinflammation.

Jae Kyu Ryu
Victoria A. Rafalski
Katerina Akassoglou
Research15 Oct 2018
Nature Immunology

Volume: 19, P: 1212-1223
Multiferroicity in plastically deformed SrTiO₃

Plastic deformation induces robust magnetism in SrTiO3, which is completely absent in pristine samples. This magnetism coexists with ferroelectric order, showcasing plastic deformation as a powerful tool for manipulating quantum material properties.

Xi Wang
Anirban Kundu
Avraham Klein
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-10
Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

Debra Van Egeren
Khushi Kohli
Zenta Walther
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-6
Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome

Felipe Henriques
Magno A. Lopes
Miguel L. Batista Jr.
ResearchOpen Access21 Dec 2018
Scientific Reports

Volume: 8, P: 1-14
Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

This Review examines the signalling between cells resident in adipose tissue and local sensory and sympathetic nerve fibres. The potential of targeting these processes in new therapeutics for metabolic diseases is also discussed.

Adilson Guilherme
Felipe Henriques
Michael P. Czech
Reviews07 Feb 2019
Nature Reviews Endocrinology

Volume: 15, P: 207-225
Congenital hepatic arteriovenous malformation: an unusual cause of neonatal persistent pulmonary hypertension

C P Alexander
B G Sood
M P Bedard
Research30 Mar 2006
Journal of Perinatology

Volume: 26, P: 316-318
Isotope array analysis of Rhodocyclales uncovers functional redundancy and versatility in an activated sludge

Martin Hesselsoe
Stephanie Füreder
Alexander Loy
Research02 Jul 2009
The ISME Journal

Volume: 3, P: 1349-1364

Search

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization

FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Multiferroicity in plastically deformed SrTiO₃

Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

Congenital hepatic arteriovenous malformation: an unusual cause of neonatal persistent pulmonary hypertension

Isotope array analysis of Rhodocyclales uncovers functional redundancy and versatility in an activated sludge

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