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Showing 1–7 of 7 results
Advanced filters: Author: Alexander Hergovich Clear advanced filters

  • The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how they differently affect development, tissue growth and tumor suppression.

    • Yavuz Kulaberoglu
    • Kui Lin
    • Alexander Hergovich
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sorafenib treatment in cancer cells.

    • Fengyuan Tang
    • Ruize Gao
    • Gerhard Christofori
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Cancer-associated mutations in isocitrate dehydrogenase are proposed to impair TET2-dependent DNA demethylation. By comparing the methylomes of IDH-mutant cancers, the authors identify the transcription factor EBF1 as a partner of TET2, suggesting a possible means for targeting TET2 to specific DNA sequences.

    • Paul Guilhamon
    • Malihe Eskandarpour
    • Stephan Beck
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-9

  • The NDR protein kinases regulate morphological changes, mitotic exit, cytokinesis, cell proliferation and apoptosis, as well as neuronal growth and differentiation. Combined data from different model organisms now highlight the conserved roles of these kinases in physiology and disease.

    • Alexander Hergovich
    • Mario R. Stegert
    • Brian A. Hemmings
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 253-264

  • The tumour suppressor protein VHL, which is inactivated in hereditary and sporadic forms of renal cell carcinoma, is found at the mitotic spindle in mammalian cells. VHL inactivation leads to unstable astral microtubules and spindle misorientation as well as to reduced levels of Mad2, resulting in spindle checkpoint weakening and genomic instability.

    • Claudio R. Thoma
    • Alberto Toso
    • Wilhelm Krek
    Research
    Nature Cell Biology
    Volume: 11, P: 994-1001