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Showing 1–4 of 4 results
Advanced filters: Author: Alexander Hillisch Clear advanced filters

  • The synaptic vesicle protein 2 family are essential membrane proteins found in the brain that bind synaptotagmin and are targeted by anti-seizure medications. Structures reveal common features found in transport proteins, and the basis of ligand binding and selectivity.

    • Anshumali Mittal
    • Matthew F. Martin
    • Jonathan A. Coleman
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1964-1974

  • Critical Assessment of Computational Hit-finding Experiments (CACHE) is a public benchmarking project to compare and improve computational small-molecule hit-finding approaches through cycles of prediction, compound synthesis and experimental testing. By that, CACHE will enable a more efficient and effective approach to hit identification and drug discovery.

    • Suzanne Ackloo
    • Rima Al-awar
    • Timothy M. Willson
    Reviews
    Nature Reviews Chemistry
    Volume: 6, P: 287-295

  • The nucleophilic substitution reaction (SN2) is one of the oldest yet very useful organic transformations, but surprisingly, the nucleophilic character of isocyanides has never been explored in SN2 reactions. Here the authors show that isocyanides react as versatile nucleophiles in SN2 reactions with alkyl halides in a general manner to afford highly substituted secondary amides by in situ hydrolysis of the intermediate nitrilium ion.

    • Pravin Patil
    • Qiang Zheng
    • Alexander Dömling
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9