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Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

Adoptive T cell therapy has shown remarkable promise for the treatment of haematological malignancies. Here, the authors show that a cryogel platform for the simultaneous delivery of autologous T cells and recruitment of local antigen-presenting cells promotes long-lasting responses against solid tumours in mice.

Kwasi Adu-Berchie
Joshua M. Brockman
David J. Mooney
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-15
A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia

A macroporous material encapsulating an immune-cell-activating cytokine, an adjuvant and tumour-associated antigens elicits prophylactic immunity to acute myeloid leukaemia in mice, and eradicates the disease when combined with chemotherapy.

Nisarg J. Shah
Alexander J. Najibi
David J. Mooney
Research14 Jan 2020
Nature Biomedical Engineering

Volume: 4, P: 40-51
Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve immunotherapy efficacy in triple negative breast cancer models.

Hua Wang
Alexander J. Najibi
David J. Mooney
ResearchOpen Access10 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Durable lymph-node expansion is associated with the efficacy of therapeutic vaccination

Durable and robust lymph-node expansion is associated with the efficacy of therapeutic vaccination, as shown in mice immunized via a biomaterial-based vaccine.

Alexander J. Najibi
Ryan S. Lane
David J. Mooney
ResearchOpen Access06 May 2024
Nature Biomedical Engineering

Volume: 8, P: 1226-1242
Matrix viscoelasticity controls spatiotemporal tissue organization

Viscoelasticity is a universal mechanical feature of the extracellular matrix. Here the authors show that the extracellular matrix viscoelasticity guides tissue growth and symmetry breaking, a fundamental process in morphogenesis and oncogenesis.

Alberto Elosegui-Artola
Anupam Gupta
David J. Mooney
Research01 Dec 2022
Nature Materials

Volume: 22, P: 117-127
Active tissue adhesive activates mechanosensors and prevents muscle atrophy

An implantable tissue adhesive soft actuator adheres to muscle, generating mechanical stimulation, and activates mechanosensing pathways for prevention of atrophy in disuse muscles.

Sungmin Nam
Bo Ri Seo
David J. Mooney
Research10 Nov 2022
Nature Materials

Volume: 22, P: 249-259
Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds

This protocol describes the synthesis and applications of artificial antigen-presenting cell scaffolds. The scaffolds can be used for efficient ex vivo polyclonal T-cell expansion and antigen-specific enrichment of rare T-cell subpopulations.

David K. Y. Zhang
Alexander S. Cheung
David J. Mooney
Protocols13 Jan 2020
Nature Protocols

Volume: 15, P: 773-798

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Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia

Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

Durable lymph-node expansion is associated with the efficacy of therapeutic vaccination

Matrix viscoelasticity controls spatiotemporal tissue organization

Active tissue adhesive activates mechanosensors and prevents muscle atrophy

Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds

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