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Showing 1–4 of 4 results
Advanced filters: Author: Alexander Kowar Clear advanced filters

  • The control of translation during mitosis has an important role in cancer cell biology. Here the authors report that in mitotically arrested cancer cells, redistribution of ribosomes towards upstream open reading frames results in enhanced presentation of immunogenic peptides on cancer cell surface.

    • Alexander Kowar
    • Jonas P. Becker
    • Fabricio Loayza-Puch
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The tumor microenvironment influences the metabolic behavior of cancer cells. Here, using Dual Ribosome Profiling, the authors uncover a cancer-stromal cell interaction under glucose starvation that increases nutrient availability, in response to type I interferon. In addition, in vivo, immune checkpoint blockade triggers metabolic constraints in T cells, reducing their proliferation and cytotoxicity.

    • Daniela Aviles-Huerta
    • Rossella Del Pizzo
    • Fabricio Loayza-Puch
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Synthesizing the cellular proteome is demanding and finely regulated. Here, the authors show that mTORC1 cooperates with tRNA wobble modification to promote ribosomal protein synthesis, thus supporting the high translational demands of cell growth.

    • Julia Hermann
    • Toman Borteçen
    • Wilhelm Palm
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19