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Heterogeneous endocrine cell composition defines human islet functional phenotypes

Our investigation highlights substantial heterogeneity in islet cell composition associated with hormone secretory traits, sex, reported race and ethnicity, genetically predicted ancestry, and genetic risk for type 2 diabetes (T2D).

Carmella Evans-Molina
Yasminye D. Pettway
Marcela Brissova
ResearchOpen Access12 May 2026
Nature Communications

Volume: 17, P: 1-21
Genetic risk converges on regulatory networks mediating early type 2 diabetes

Integration of multiomics data with functional analysis of pancreatic tissues from individuals with early-stage type 2 diabetes indicates that the genetic risk converges on RFX6, which regulates chromatin architecture at multiple risk loci.

John T. Walker
Diane C. Saunders
Marcela Brissova
Research04 Dec 2023
Nature

Volume: 624, P: 621-629
Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration

Diane C. Saunders
Kristie I. Aamodt
Marcela Brissova
ResearchOpen Access06 Apr 2021
npj Regenerative Medicine

Volume: 6, P: 1-13