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Showing 1–13 of 13 results
Advanced filters: Author: Alexander Mendenhall Clear advanced filters

  • Random monoallelic expression affects everything from the penetrance of genetic disease to immune cell function. Here, the authors found that epigenetic monoallelic expression is regulated in early embryos by two conserved maternal histone methyltransferases.

    • Bryan Sands
    • Soo R. Yun
    • Alexander R. Mendenhall
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or intrinsic noise in adult intestine cells.

    • Nikolay Burnaevskiy
    • Bryan Sands
    • Alexander Mendenhall
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Stochastic autosomal allele expression bias has been widely documented, yet the mechanisms behind this consequential phenomenon remain poorly understood. Here the authors show that the presence of introns greatly restricts monoallelic expression in a C. elegans model.

    • Bryan Sands
    • Soo Yun
    • Alexander R. Mendenhall
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Mendenhall et al. use a locally constructed measure of stress and a mixed-methods approach to investigate a syndemic in Soweto, South Africa. Stress interacted with multiple morbidities to reduce quality of life, conditioned by illness experiences.

    • Emily Mendenhall
    • Andrew Wooyoung Kim
    • Alexander C. Tsai
    Research
    Nature Human Behaviour
    Volume: 6, P: 64-73

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • Single-molecule-based sequencing technology is applied to generate genome-wide maps of chromatin modifications in mammalian cells. Histone marks can discriminate genes that are active, poised for activation, or stably repressed and therefore reflect cell state and developmental potential.

    • Tarjei S. Mikkelsen
    • Manching Ku
    • Bradley E. Bernstein
    Research
    Nature
    Volume: 448, P: 553-560

  • This Perspective delivers an introduction to syndemic thinking, and provides insights into how epidemics interact and what scientists, clinicians and policymakers can do with this information.

    • Emily Mendenhall
    • Brandon A. Kohrt
    • Alexander C. Tsai
    Reviews
    Nature Medicine
    Volume: 28, P: 1359-1362

  • The Mediterranean diet correlates with increased human lifespan; it is rich in foods with high levels of cis-monounsaturated fatty acids (MUFAs), such as olive oil. A study now shows that MUFAs stimulate a lipid droplet–peroxisome organelle network to decrease lipid oxidation and protect cell membranes during ageing.

    • Alexander Richard Mendenhall
    News & Views
    Nature Cell Biology
    Volume: 25, P: 627-628

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698