Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–21 of 21 results
Advanced filters: Author: Alexander N. Combes Clear advanced filters

  • Difficulties can be encountered when translating research between cells from animals and humans because of gene expression differences. Here the authors perform an integrative transcriptomic analysis from human and mouse neutrophils and identify a core inflammation program shared across inflamed contexts.

    • Nicolaj S. Hackert
    • Felix A. Radtke
    • Ricardo Grieshaber-Bouyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of patients with self-limiting upper respiratory SARS-CoV-2 infection and reveal a temporal immune trajectory they associate with viral containment and restriction from pneumonic progressive disease.

    • Kami Pekayvaz
    • Alexander Leunig
    • Leo Nicolai
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Patients with mild COVID-19 show a pattern of interferon-stimulated gene (ISG) expression across all major cell types, but in patients with severe disease, antibodies block the production of these ISG-expressing cells.

    • Alexis J. Combes
    • Tristan Courau
    • Matthew F. Krummel
    Research
    Nature
    Volume: 591, P: 124-130

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • A transcriptional analysis of kidney organoids reveals batch effects as the key drivers of variation, mainly through differences in maturity, and provides a list of highly variable genes and a method for estimating differentiation stage for improved disease modeling.

    • Belinda Phipson
    • Pei X. Er
    • Melissa H. Little
    Research
    Nature Methods
    Volume: 16, P: 79-87

  • Aurora, a new large-scale foundation model trained on more than one million hours of diverse geophysical data, outperforms operational forecasts in predicting air quality, ocean wave dynamics, tropical cyclone tracks and high-resolution weather.

    • Cristian Bodnar
    • Wessel P. Bruinsma
    • Paris Perdikaris
    ResearchOpen Access
    Nature
    Volume: 641, P: 1180-1187

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

    • Natasha Spottiswoode
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regulating the duration of nephrogenesis.

    • Alena V. Yermalovich
    • Jihan K. Osborne
    • George Q. Daley
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Dexamethasone has been used in the treatment of critically ill COVID-19 patients. Here the authors apply transcriptomics to investigate the effects of dexamethasone treatment in COVID-19 patients, and show both systemic and compartment-specific effects.

    • Lucile P. A. Neyton
    • Ravi K. Patel
    • Gabriela K. Fragiadakis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.

    • Aartik Sarma
    • Stephanie A. Christenson
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Human renal tissues can now be generated from human pluripotent stem cells in vitro. Here, Melissa Little and colleagues explore how improved understanding of renal development has guided differentiation protocols to generate kidney cellsin vitroand discuss the potential applications for these cells in nephrology.

    • Melissa H. Little
    • Alexander N. Combes
    • Minoru Takasato
    Reviews
    Nature Reviews Nephrology
    Volume: 12, P: 624-635

  • In this Protocol, data obtained from optical projection tomography and confocal microscopy is analyzed with Tree Surveyor and Imaris to obtain information about branching morphogenesis. Mouse kidneys are used as an example, but the method is applicable to other branched organs.

    • Alexander N Combes
    • Kieran M Short
    • Ian M Smyth
    Protocols
    Nature Protocols
    Volume: 9, P: 2859-2879