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Target sequence-conditioned design of peptide binders using masked language modeling

PepMLM designs peptide binders against diverse targets using masked language modeling.

Leo Tianlai Chen
Zachary Quinn
Pranam Chatterjee
ResearchOpen Access13 Aug 2025
Nature Biotechnology

P: 1-9
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Jonathan Cohen
Alexander Pertsemlidis
Helen H Hobbs
Research16 Jan 2005
Nature Genetics

Volume: 37, P: 161-165
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Helen Hobbs and colleagues report an association between coding variation in PNPLA3 and susceptibility to nonalcoholic fatty liver disease. The associated alleles vary in frequency among Hispanics, African Americans and European Americans and contribute to differences in disease prevalence among these ancestry groups.

Stefano Romeo
Julia Kozlitina
Helen H Hobbs
Research25 Sept 2008
Nature Genetics

Volume: 40, P: 1461-1465
Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

Human memory B cells differentiate from naïve B cells and can express different immunoglobulin (Ig) isotypes resulted from class-switch recombination. Here the authors describe, using transcriptional and epigenetic data from human memory B cells and integrated multi-omics analyses, the differentiation regulation and trajectory of IgG⁺, IgA⁺ and IgD⁺ memory B cells.

Justin B. Moroney
Anusha Vasudev
Paolo Casali
ResearchOpen Access28 Oct 2020
Nature Communications

Volume: 11, P: 1-18
miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

Xiaojie Yu
Yiqiang Zhang
Alexander Pertsemlidis
ResearchOpen Access07 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-12
A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

Jing Lin
Roza Zandi
Lin Ji
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-11

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Target sequence-conditioned design of peptide binders using masked language modeling

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

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Target sequence-conditioned design of peptide binders using masked language modeling

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

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