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Showing 1–5 of 5 results
Advanced filters: Author: Alexander S. Garruss Clear advanced filters

  • Embryonic stem cells (ESCs) possess a unique chromatin landscape in which 'bivalent' domains of trimethylated histone H3 Lys4 (H3K4me3) and Lys27 (H3K27me3) mark key lineage-specific genes. A new study now reports the identification of Mll2 (KMT2b) as the enzyme responsible for implementing H3K4me3 on bivalently marked promoters in ESCs.

    • Deqing Hu
    • Alexander S Garruss
    • Ali Shilatifard
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1093-1097

  • RNA can be used as a programmable tool for detection of biological analytes. Here the authors use deep neural networks to predict toehold switch functionality in synthetic biology applications.

    • Nicolaas M. Angenent-Mari
    • Alexander S. Garruss
    • James J. Collins
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Jeramiah Smith, Weiming Li and colleagues report the whole-genome sequence of the sea lamprey, Petromyzon marinus, representing a vertebrate lineage diverged from humans ~500 million years ago. Their analyses define key evolutionary events in vertebrate lineages and provide evidence for two whole-genome duplication events occurring before the divergence of the ancestral lamprey and jawed vertebrate (gnathostome) lineages.

    • Jeramiah J Smith
    • Shigehiro Kuraku
    • Weiming Li
    ResearchOpen Access
    Nature Genetics
    Volume: 45, P: 415-421