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Showing 1–12 of 12 results
Advanced filters: Author: Alexander Schleiffer Clear advanced filters

  • Cohesin functions must be tightly regulated. Here Prusén Mota et al. show that the cohesin regulator SORORIN is conserved beyond the animal kingdom and they provide the first organismal in vivo evidence that SORORIN antagonizes WAPL.

    • Ignacio Prusén Mota
    • Marta Galova
    • Peter Schlögelhofer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The egg membrane protein Bouncer is an important mediator of gamete interaction and prevents cross-fertilisation between medaka and zebrafish. This study demonstrates unique functional and structural differences in Bouncer proteins of these and other distantly related fish species which may determine which species can hybridize.

    • Krista R. B. Gert
    • Karin Panser
    • Andrea Pauli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The full-length structure of HUWE1 reveals the bipartite organization of a giant E3 ubiquitin ligase, comprising a catalytic HECT domain and a large, ring-shaped scaffold that provides docking sites for various substrates and regulates E3 activity.

    • Daniel B. Grabarczyk
    • Olga A. Petrova
    • Tim Clausen
    Research
    Nature Chemical Biology
    Volume: 17, P: 1084-1092

  • Cohesin is a ring-shaped protein complex that structures chromatin and mediates sister chromatid cohesion. Here the authors rigidify cohesin using engineered Smc1 and Smc3 and generated 3D models showing how Pds5B forms an integral part of the cohesin ring.

    • Michael T. Hons
    • Pim J. Huis in ‘t Veld
    • Jan-Michael Peters
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Structural and biochemical characterization of arginine kinase McsB reveals how its phosphagen kinase–like catalytic domain is adapted to target protein substrates while its phosphoarginine-binding domain allosterically controls kinase activity.

    • Marcin J. Suskiewicz
    • Bence Hajdusits
    • Tim Clausen
    Research
    Nature Chemical Biology
    Volume: 15, P: 510-518

  • Multi-protein kinetochore complexes bind to the centromeric region of chromosomes to ensure accurate spindle attachment and chromosome segregation, although centromere organization differs widely between species. Westermann and colleagues now identify the budding yeast protein Cnn1 as the orthologue of mammalian CENP-T. They show that it binds to the Ndc80 kinetochore complex and functions in chromosome segregation, illustrating a conserved role for this protein.

    • Alexander Schleiffer
    • Michael Maier
    • Stefan Westermann
    Research
    Nature Cell Biology
    Volume: 14, P: 604-613