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Showing 1–15 of 15 results
Advanced filters: Author: Alexander Tyshkovskiy Clear advanced filters

  • Heterochronic parabiosis ameliorates age-related diseases in mice, but how it affects epigenetic aging and long-term health was not known. Here, the authors show that in mice exposure to young circulation leads to reduced epigenetic aging, an effect that persists for several months after removing the youthful circulation.

    • Bohan Zhang
    • David E. Lee
    • James P. White
    Research
    Nature Aging
    Volume: 3, P: 948-964

  • At single-cell resolution, Tarkhov et al. delineate stochastic and co-regulated components of epigenetic aging, revealing a simultaneous loss of regulation at the epigenetic and transcriptional levels in aging.

    • Andrei E. Tarkhov
    • Thomas Lindstrom-Vautrin
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 4, P: 854-870

  • Previous studies have identified common genetic variants linked to longevity, but the impact of rare damaging mutations remains unclear. Here, the authors show that centenarians carry fewer harmful loss-of-function mutations and identify genes that may contribute to extreme longevity and healthy aging

    • Kejun Ying
    • José P. Castro
    • Vadim N. Gladyshev
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • On 1–2 November 2024, the annual Biomarkers of Aging conference welcomed academic and industry scientists, and partners from governmental and nongovernmental organizations, to Harvard Medical School in Boston, USA, to discuss new insights into measuring and monitoring human aging, with the aim of clinical translation. In this Meeting Report, we summarize the conference and offer potential future directions for the Biomarkers of Aging Consortium and the longevity science community at large.

    • Erik Jacques
    • Chiara Herzog
    • Vadim N. Gladyshev
    News & Views
    Nature Aging
    Volume: 5, P: 539-543

  • Dissecting the effects of hypothermic and hypometabolic states on aging processes, the authors show that activation of neurons in the preoptic area induces a torpor-like state in mice that slows epigenetic aging and improves healthspan. These pro-longevity effects are mediated by reduced Tb, reinforcing evidence that Tb is a key mediator of aging processes.

    • Lorna Jayne
    • Aurora Lavin-Peter
    • Sinisa Hrvatin
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 437-449

  • Ying, Paulson and collagues have developed an open-source framework, Biolearn, to harmonize and systematically evaluate 39 aging biomarkers across diverse populations, enabling standardized validation and facilitating development of robust aging biomarkers.

    • Kejun Ying
    • Seth Paulson
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 5, P: 2323-2339

  • Castro, Shindyapina et al. explore how aging promotes B cell lymphoma in mice, identifying a population of age-associated clonal B cells that expands through mutation, c-Myc activation and epigenetic alterations to drive age-associated malignancy.

    • José P. Castro
    • Anastasia V. Shindyapina
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 4, P: 1403-1417

  • Aguado et al. show that SARS-CoV-2 induces senescence in human brain organoids and in the brains of COVID-19-infected mice and humans. They demonstrate the therapeutic potential of senolytic therapy in protection against COVID-19-induced brain aging.

    • Julio Aguado
    • Alberto A. Amarilla
    • Ernst J. Wolvetang
    ResearchOpen Access
    Nature Aging
    Volume: 3, P: 1561-1575

  • The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immortal. Here Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea, and global reversal of such changes after regeneration.

    • Xiaoting Dai
    • Xinghua Li
    • Longhua Guo
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 780-798

  • Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the mechanisms that promote tolerance of aneuploidy.

    • Alaattin Kaya
    • Marco Mariotti
    • Vadim N. Gladyshev
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation through several pathways, extended lifespan and improved healthspan.

    • Zhihui Zhang
    • Xiao Tian
    • Vera Gorbunova
    Research
    Nature
    Volume: 621, P: 196-205