Nature Search

Subversion of the innate immune system by a retrovirus

Brooke A Jude
Yelena Pobezinskaya
Tatyana V Golovkina
Research05 May 2003
Nature Immunology

Volume: 4, P: 573-578
Nobels: Toll pioneers deserve recognition

James P. Allison
Christophe Benoist
Alexander V. Chervonsky
Correspondence09 Nov 2011
Nature

Volume: 479, P: 178
Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Xiaoxiao Wan
Anthony N. Vomund
Emil R. Unanue
Amendments and Corrections01 Apr 2020
Nature Immunology

Volume: 21, P: 589
Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression

Androgen is a sex hormone that may contribute to sex biases in autoimmunity. Here the authors show that in T cells androgen induces the expression of Ptpn22 phosphatase to negatively regulate T cell activation, thereby contributing to protecting males from major autoimmune diseases such as systemic lupus erythematosus and type 1 diabetes.

Jean Lee
Leonid A. Yurkovetskiy
Alexander V. Chervonsky
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-19
T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity

Pasare and colleagues describe an inflammasome-independent, TNFR–Fas–caspase-8-dependent pathway of IL-1β production triggered by cognate interactions between effector CD4⁺ T cells and mononuclear phagocytes.

Aakanksha Jain
Ricardo A. Irizarry-Caro
Chandrashekhar Pasare
Research17 Dec 2019
Nature Immunology

Volume: 21, P: 65-74
Solving the plot: early events are the key to diabetes intervention

Type 1 diabetes is usually diagnosed after most insulin-producing islets of Langerhans have already been destroyed. However, magnetic resonance imaging can be used to predict the onset of type 1 diabetes, and a benign prognosis correlates with the presence of anti-inflammatory tissue-resident macrophages.

Alexander V Chervonsky
News & Views19 Mar 2012
Nature Immunology

Volume: 13, P: 311-312
The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Unanue and colleagues examine the immunopeptidome of pancreatic islets in non-obese diabetic (NOD) mice, which spontaneously develop autoimmune diabetes, to reveal the key features of a restricted component in the self-MHC-II peptidome that causes autoreactivity.

Xiaoxiao Wan
Anthony N. Vomund
Emil R. Unanue
Research09 Mar 2020
Nature Immunology

Volume: 21, P: 455-463
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the lactating mammary gland, which was driven by thymic and intestinal inputs and was sensitive to changes in the microbiota

Abigail Jaquish
Eleni Phung
Deepshika Ramanan
Research29 Jul 2025
Nature Immunology

Volume: 26, P: 1411-1422
Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Systemic exposure to Toll-like receptor (TLR) ligands during sickness is shown to induce fucosylation of the small intestine in mice; some of the fucose is shed into the intestinal lumen, where it provides nourishment for the microbiota.

Joseph M. Pickard
Corinne F. Maurice
Alexander V. Chervonsky
Research01 Oct 2014
Nature

Volume: 514, P: 638-641
Innate immunity and intestinal microbiota in the development of Type 1 diabetes

The effect of deficiency of MyD88 on the generation of type 1 diabetes (T1D) has been investigated through the generation of congenic strains in the non-obese diabetic (NOD) mouse model. It is found that in specific pathogen-free conditions, MyD88-deficiency attenuates T1D, indicating that the interaction of intestinal microbes with the innate immune system is a critical factor in modifying susceptibility to type 1 diabetes.

Li Wen
Ruth E. Ley
Alexander V. Chervonsky
Research21 Sept 2008
Nature

Volume: 455, P: 1109-1113
Influence of microbial environment on autoimmunity

Alexander V Chervonsky
Reviews17 Dec 2009
Nature Immunology

Volume: 11, P: 28-35

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