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Showing 1–3 of 3 results
Advanced filters: Author: Alexander Zheleznyak Clear advanced filters

  • High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 therapy.

    • Reza Ghasemi
    • Eric Lazear
    • Alexander Sasha Krupnick
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • Climate change strongly impacts regions in high latitudes and altitudes that store high amounts of carbon in yet frozen ground. Here the authors show that the consequence of these changes is global warming of permafrost at depths greater than 10 m in the Northern Hemisphere, in mountains, and in Antarctica.

    • Boris K. Biskaborn
    • Sharon L. Smith
    • Hugues Lantuit
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11