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Showing 1–5 of 5 results
Advanced filters: Author: Alexandra B. Firsova Clear advanced filters

  • Using multiplexed spatially resolved transcriptomic approaches, the authors generate a topographic atlas of the healthy adult lung with location-related gene expression variability or neighbourhood changes as exemplified by COPD patient sample analysis.

    • Alexandra B. Firsova
    • Sergio Marco Salas
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Secretory cells are major constituents of the lung airways, but their diversity, organization and specification are partially understood. Here, single-cell analysis reveals a differentiation gradient: proximal airway regions specialize in innate immunity, distal regions in lipid metabolism, while intermediate cells express low levels of both programs, driven by Fgfr2 signaling.

    • Alexandros Sountoulidis
    • Jonas Theelke
    • Christos Samakovlis
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-21

  • Spapros is a probe set selection pipeline for targeted spatial transcriptomics that optimizes for both transcriptional and within-cell type variation.

    • Louis B. Kuemmerle
    • Malte D. Luecken
    • Fabian J. Theis
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 2260-2270

  • Spatial transcriptomics relies on RNA quality, which is variable and dependent on sample handling, storage, and/or intrinsic factors. Here, authors present a genome-wide spatial gene expression profiling method called RNA Rescue Spatial Transcriptomics (RRST), designed for the analysis of moderate to low quality fresh frozen tissue samples and demonstrate its robustness on 7 different tissue types.

    • Reza Mirzazadeh
    • Zaneta Andrusivova
    • Joakim Lundeberg
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16