The authors developed a rat model for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), using a minimal future liver remnant considered to be insufficient for survival. An in situ split combined with portal vein ligation boosts liver hypertrophy, and hepatectomy induces a higher level of hepatocyte proliferation, resulting in increased liver mass recovery and survival after ALPPS. This robust model should be valuable for studying the physiological mechanisms leading to accelerated regeneration.
- Alexandra Dili
- Valérie Lebrun
- Isabelle A. Leclercq
