Nature Search

Crusading appeal

Alexandra Dixon
Brian Bertram
Books & Arts15 Jan 1987
Nature

Volume: 325, P: 205
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

Volume: 646, P: 1146-1155
Adenosine–deaminase–deficient mice die perinatally and exhibit liver–cell degeneration, atelectasis and small intestinal cell death

Alexandra A.J. Migchielsen
Marco L. Breuer
Dinko Valerio
Research01 Jul 1995
Nature Genetics

Volume: 10, P: 279-287
Essential role of Mash-2 in extraembryonic development

François Guillemot
Andras Nagy
Alexandra L. Joyner
Research22 Sept 1994
Nature

Volume: 371, P: 333-336
Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

Alexandra L. Joyner
William C. Skarnes
Janet Rossant
Research09 Mar 1989
Nature

Volume: 338, P: 153-156
Delineating cysteine-reactive compound modulation of cellular proteostasis processes

A cysteine-reactive degrader of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 14 (nsp14) was identified, which mediates degradation through electrophile-induced global protein ubiquitylation, proteasome activation and the formation of stress granules and aggresomes.

Ashley R. Julio
Flowreen Shikwana
Keriann M. Backus
Research24 Oct 2024
Nature Chemical Biology

Volume: 21, P: 693-705
The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

Berkane et al. investigated the activation process of selective autophagy of the ER. They show that that phosphorylation of FAM134 proteins by CK2 is a prerequisite for the formation of large micro-clusters of high-density at the ER membrane.

Rayene Berkane
Hung Ho-Xuan
Alexandra Stolz
ResearchOpen Access15 Dec 2023
Nature Communications

Volume: 14, P: 1-17
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
Research18 Apr 2024
Nature Genetics

Volume: 56, P: 792-808
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
ResearchOpen Access08 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Design and testing of a humanized porcine donor for xenotransplantation

Using kidneys from a genetically engineered porcine donor transplanted into a cynomolgus monkey model, the design, creation and long-term function of kidney grafts supporting life are explored.

Ranjith P. Anand
Jacob V. Layer
Wenning Qin
ResearchOpen Access11 Oct 2023
Nature

Volume: 622, P: 393-401
Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing

Using two independent knockout mouse models, the authors show that loss of Klhdc7b, a candidate for susceptibility to age-related hearing loss in humans, results in an early and progressive hearing loss, confirming Klhdc7b’s role in the maintenance of hearing.

Alexandra M. Kaufman
Benjamin Silver
Sally J. Dawson
ResearchOpen Access17 Dec 2025
Communications Biology

Volume: 9, P: 1-16
Complement genes contribute sex-biased vulnerability in diverse disorders

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Nolan Kamitaki
Aswin Sekar
Steven A. McCarroll
Research11 May 2020
Nature

Volume: 582, P: 577-581
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

A chemogenetic approach was developed for cell-type-specific drug-inducible protein synthesis inhibition in mice. It was used to show that consolidation of long-term aversive memories requires rapid neuronal protein synthesis in the amygdala.

Prerana Shrestha
Pinar Ayata
Eric Klann
Research20 Jan 2020
Nature Neuroscience

Volume: 23, P: 281-292
Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Doretta Caramaschi
Alexander Neumann
Gemma Sharp
ResearchOpen Access10 Feb 2022
Molecular Psychiatry

Volume: 27, P: 2126-2135
Review: the use of sodium hypochlorite in endodontics — potential complications and their management

H. R. Spencer
V. Ike
P. A. Brennan
Research12 May 2007
British Dental Journal

Volume: 202, P: 555-559
Epigenetic clocks in relapse after a first episode of schizophrenia

Àlex-González Segura
Llucia Prohens
Leticia González-Blanco
ResearchOpen Access22 Jul 2022
Schizophrenia

Volume: 8, P: 1-8
A threshold nuclear level of the v-Rel oncoprotein is required for transformation of avian lymphocytes

Shrikesh Sachdev
J Alan Diehl
Mark Hannink
Research29 May 1997
Oncogene

Volume: 14, P: 2585-2594
Rare copy number variation in posttraumatic stress disorder

Adam X. Maihofer
Worrawat Engchuan
Caroline M. Nievergelt
ResearchOpen Access21 Sept 2022
Molecular Psychiatry

Volume: 27, P: 5062-5069
Population-scale analysis of common and rare genetic variation associated with hearing loss in adults

A GWAS and exome-wide association study meta-analysis identifies 53 loci affecting hearing loss risk from over half a million individuals across five cohorts. Rare variants in Mendelian hearing loss genes contribute to hearing loss risk in adults.

Kavita Praveen
Lee Dobbyn
Giovanni Coppola
ResearchOpen Access03 Jun 2022
Communications Biology

Volume: 5, P: 1-12
Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy

S Bowyer
P Prithviraj
O Klein
ResearchOpen Access28 Apr 2016
British Journal of Cancer

Volume: 114, P: 1084-1089
An open resource for transdiagnostic research in pediatric mental health and learning disorders

Lindsay M. Alexander
Jasmine Escalera
Michael P. Milham
ResearchOpen Access19 Dec 2017
Scientific Data

Volume: 4, P: 1-26
DASH, the data and specimen hub of the National Institute of Child Health and Human Development

Rohan Hazra
Susan Tenney
David Songco
ResearchOpen Access20 Mar 2018
Scientific Data

Volume: 5, P: 1-10

Search

Crusading appeal

Polygenic and developmental profiles of autism differ by age at diagnosis

Adenosine–deaminase–deficient mice die perinatally and exhibit liver–cell degeneration, atelectasis and small intestinal cell death

Essential role of Mash-2 in extraembryonic development

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

Delineating cysteine-reactive compound modulation of cellular proteostasis processes

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Design and testing of a humanized porcine donor for xenotransplantation

Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing

Complement genes contribute sex-biased vulnerability in diverse disorders

Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Review: the use of sodium hypochlorite in endodontics — potential complications and their management

Epigenetic clocks in relapse after a first episode of schizophrenia

A threshold nuclear level of the v-Rel oncoprotein is required for transformation of avian lymphocytes

Rare copy number variation in posttraumatic stress disorder

Population-scale analysis of common and rare genetic variation associated with hearing loss in adults

Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy

An open resource for transdiagnostic research in pediatric mental health and learning disorders

DASH, the data and specimen hub of the National Institute of Child Health and Human Development

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