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Showing 1–6 of 6 results
Advanced filters: Author: Alexandra M. Haugh Clear advanced filters

  • Rare cells are often biologically and clinically important, but their low abundance makes them challenging to study using single-cell transcriptomics. Here, the authors develop PURE-seq which integrates FACS and PIP-seq to directly sequence ultra-rare cells. It captures cells at 1 in 1,000,000 rarity, which the authors demonstrate by profiling circulating tumor cells and identifying Egr1 as a regulator of mouse hematopoietic stem cell aging.

    • Sixuan Pan
    • Inés Fernández-Maestre
    • Adam R. Abate
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Porous materials are technologically important for a wide range of applications, such as catalysis and separation. Covalently bonded organic cages can now be assembled into crystalline microporous materials, and their porosity is found to be intrinsic to their molecular cage structure.

    • Tomokazu Tozawa
    • James T. A. Jones
    • Andrew I. Cooper
    Research
    Nature Materials
    Volume: 8, P: 973-978

  • The highest-energy stereoisomer of 1,2,3,4,5,6-hexafluorocyclohexane, with all the fluorines ‘up’, has been prepared in a 12-step protocol. The molecule adopts a chair conformation with three triaxial C–F bonds on one face generating a polarized ring. In the solid state the molecules pack in an orientation consistent with electrostatic ordering.

    • Neil S. Keddie
    • Alexandra M. Z. Slawin
    • David O'Hagan
    Research
    Nature Chemistry
    Volume: 7, P: 483-488

  • Tetrathiafulvalene (TTF)-based [3]catenanes are shown to display multiple stable redox states dominated by TTF···TTF radical dimer interactions occurring within the cavity of what is essentially a ‘molecular flask’. These stabilizing interactions are found to be the basis of a novel recognition motif that can be employed to drive molecular switching under redox control.

    • Jason M. Spruell
    • Ali Coskun
    • J. Fraser Stoddart
    Research
    Nature Chemistry
    Volume: 2, P: 870-879