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Showing 1–8 of 8 results
Advanced filters: Author: Alexandra T. Keinath Clear advanced filters

  • Recent work has shown that the tuning of hippocampal place cells changes unexpectedly across weeks, a phenomenon known as neural drift. Keinath et al. show that this drift occurs in a particular way, one which preserves the representation of context.

    • Alexandra T. Keinath
    • Coralie-Anne Mosser
    • Mark P. Brandon
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Keinath et al. show that information about the recent past is represented in the hippocampus through changes in firing rates in the absence of task demands. This representation is eliminated when DG–CA3 circuitry is inhibited.

    • Alexandra T. Keinath
    • Andrés Nieto-Posadas
    • Mark P. Brandon
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Geometry is crucial in spatial reorientation, but the underlying neural mechanisms of spatial reorientation are unclear. Here, the authors show that in a two-context reorientation task, distinct CA1 cells code heading retrieval and context recognition during reorientation.

    • Celia M. Gagliardi
    • Marc E. Normandin
    • Isabel A. Muzzio
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • It remains poorly understood how the onset of Alzheimer’s disease affects spatial cognition. Here, the authors report that spatial coding in grid cells deteriorates over time in a mouse model of Alzheimer’s disease during the early stages of pathology while place cell and head direction coding remain intact.

    • Johnson Ying
    • Alexandra T. Keinath
    • Mark P. Brandon
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Measuring neural activity in moving humans has been a longstanding challenge in neuroscience, which limits what we know about our navigational neural codes. Leveraging mobile EEG and motion capture, Griffiths et al. overcome this challenge to elucidate neural representations of direction and highlight key cross-species similarities.

    • Sergio A. Pecirno
    • Alexandra T. Keinath
    News & Views
    Nature Human Behaviour
    Volume: 8, P: 1243-1244

  • The authors show that human entorhinal cortex supports a grid cell-like representation of visual space. This visual grid pattern is stably anchored to the external visual world in a fashion analogous to rodent grid representations of navigable space.

    • Joshua B. Julian
    • Alexandra T. Keinath
    • Russell A. Epstein
    Research
    Nature Neuroscience
    Volume: 21, P: 191-194