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Showing 1–5 of 5 results
Advanced filters: Author: Alexandre D. Baffet Clear advanced filters

  • Mutations in the human WDR81 gene result in severe microcephaly. Carpentieri et al. show that mutation of WDR81, a gene coding for an endosomal regulator, alters intracellular processing of the EGF receptor, leading to reduced proliferation rates of neuronal progenitors and to microcephaly.

    • Jacopo A. Carpentieri
    • Amandine Di Cicco
    • Alexandre D. Baffet
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Coquand, Brunet Avalos et al. develop an imaging method to map basal radial glial cell division in human fetal tissue and cerebral organoids and detect abundant symmetric amplifying, but also direct neurogenic divisions bypassing intermediate progenitors.

    • Laure Coquand
    • Clarisse Brunet Avalos
    • Alexandre D. Baffet
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 698-709

  • Lindenhofer, Haendeler, Esk, Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands.

    • Dominik Lindenhofer
    • Simon Haendeler
    • Jürgen A. Knoblich
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 710-718

  • Basal progenitors are enriched in gyrencephalic species like humans contributing to neuronal expansion. Here the authors show that LGALS3BP de novo variants are related to reduced cortical complexity and area in humans and that LGALS3BP regulates neural progenitor position in organoids, human fetal tissue and mice.

    • Christina Kyrousi
    • Adam C. O’Neill
    • Silvia Cappello
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • The ability of cancer cells to migrate through small, constricted areas is limited by nuclear stiffness. Here the authors show that in turn nuclear stiffness stimulates the delivery of enzymes important for the degradation of the extracellular matrix and the formation of invadopodia in association with fibers thus opposing nuclear movement.

    • Elvira Infante
    • Alessia Castagnino
    • Philippe Chavrier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13