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Showing 1–5 of 5 results
Advanced filters: Author: Alexandre Denadai-Souza Clear advanced filters

  • The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.

    • Jean-Paul Motta
    • Alexandre Denadai-Souza
    • Nathalie Vergnolle
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Spatial transcriptomics relies on RNA quality, which is variable and dependent on sample handling, storage, and/or intrinsic factors. Here, authors present a genome-wide spatial gene expression profiling method called RNA Rescue Spatial Transcriptomics (RRST), designed for the analysis of moderate to low quality fresh frozen tissue samples and demonstrate its robustness on 7 different tissue types.

    • Reza Mirzazadeh
    • Zaneta Andrusivova
    • Joakim Lundeberg
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Single-cell profiling studies of the human gastrointestinal tract are increasing, offering an excellent opportunity to generate the first Human Gut Cell Atlas. This Roadmap presents a structured direction towards this goal and provides a detailed overview of the major challenges.

    • Matthias Zilbauer
    • Kylie R. James
    • Keith T. Wilson
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 597-614