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Showing 1–12 of 12 results
Advanced filters: Author: Alexandre Dubrac Clear advanced filters

  • Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.

    • Alexandre Dubrac
    • Steffen E. Künzel
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • In proliferative retinopathies, pathological vessels replace healthy ones, impairing vision. Here, the authors show that reprogramming the metabolic environment of retinal blood vessels from fatty acid oxidation to glycolysis promotes healthy revascularization and improves vision in proliferative retinopathy.

    • Gael Cagnone
    • Sheetal Pundir
    • Jean-Sébastien Joyal
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Tetik-Elsherbiny et al. demonstrate that the E3 ubiquitin ligase RNF20 mediates RNA polymerase II promoter-proximal pausing and alternative splicing, regulating the bioavailability and signaling of pro-angiogenic factors and angiogenesis.

    • Nalan Tetik-Elsherbiny
    • Adel Elsherbiny
    • Gergana Dobreva
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 3, P: 1199-1216

  • ZO-1, a cell junction protein, is essential for angiogenesis. Here the authors identify in endothelial cells unexpected associations of ZO-1 with stress granule proteins, such as YB-1, that are crucial for cytoprotection, implicating the ZO-1-YB-1 interaction in angiogenesis.

    • Yassine El Bakkouri
    • Rony Chidiac
    • Jean-Philippe Gratton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.

    • Gael Genet
    • Kevin Boyé
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Fibroblast growth factor receptor (FGFR) signalling is a crucial regulator of endothelial metabolism and vascular development.

    • Pengchun Yu
    • Kerstin Wilhelm
    • Michael Simons
    Research
    Nature
    Volume: 545, P: 224-228

  • Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF and PI3K activity, and that pharmacologic inhibition of PI3K prevents AVM development.

    • Roxana Ola
    • Alexandre Dubrac
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Notch signals are crucial for organization of angiogenic sprouting cells into the leading ‘tip’ and trailing ‘stalk’ cells. Here the authors show that endothelial neuropilin-1 quantitatively inhibits TGF-β/BMP signalling, explaining how Notch-mediated regulation of neuropilin-1 specifies endothelial tip and stalk cells.

    • Irene Maria Aspalter
    • Emma Gordon
    • Holger Gerhardt
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.

    • Feng Zhang
    • Claudia Prahst
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Poulet et al investigate the role for the PRL-2 phosphatase in mouse retina, and find that loss of PRL-2 impairs vascular outgrowth and arteriovenous patterning. They find that PRL-2 s regulates endothelial cell migration and sprouting angiogenesis and acts through VEGF and NOTCH1 signalling.

    • Mathilde Poulet
    • Jacinthe Sirois
    • Andreas Bikfalvi
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14