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Showing 1–5 of 5 results
Advanced filters: Author: Alexandre Mayran Clear advanced filters

  • Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.

    • Ines Desanlis
    • Yacine Kherdjemil
    • Marie Kmita
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin opening requires Tpit.

    • Alexandre Mayran
    • Kevin Sochodolsky
    • Jacques Drouin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 to enhance translation and secretory capacities.

    • Konstantin Khetchoumian
    • Aurélio Balsalobre
    • Jacques Drouin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed transcription of more posterior-located genes.

    • Hocine Rekaik
    • Lucille Lopez-Delisle
    • Denis Duboule
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 1164-1175

  • Analysis of Pax7 dynamics during pituitary lineage specification shows that Pax7 binds rapidly at uniquely marked heterochromatin pioneer sites and initiates chromatin opening that remains stable after Pax7 withdrawal, with loss of DNA hypermethylation at pioneered enhancers.

    • Alexandre Mayran
    • Konstantin Khetchoumian
    • Jacques Drouin
    Research
    Nature Genetics
    Volume: 50, P: 259-269