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Showing 1–3 of 3 results
Advanced filters: Author: Alexandre T. Fabro Clear advanced filters

  • Visceral adiposity is a risk factor for severe COVID-19, and infection of adipose tissue by SARS-CoV-2 has been reported. Here the authors confirm that human adipose tissue is a possible site for SARS-CoV-2 infection, but the degree of adipose tissue infection and the way adipocytes respond to the virus depend on the adipose tissue depot and the viral strain.

    • Tatiana Dandolini Saccon
    • Felippe Mousovich-Neto
    • Marcelo A. Mori
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Here, de Sá et al. show that Gasdermin-D is transiently activated in Leishmania-infected macrophages and promotes NLRP3 inflammasome activation, but not cell death. Gasdermin-D is cleaved into a noncanonical fragment, indicating that Leishmania subverts Gasdermin-D-mediated host response to establish leishmaniasis.

    • Keyla S. G. de Sá
    • Luana A. Amaral
    • Dario S. Zamboni
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19