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Showing 1–14 of 14 results
Advanced filters: Author: Alexei A. Aravin Clear advanced filters

  • The genome encodes thousands of small RNAs that interact with PIWI proteins; these PIWI-interacting RNAs (piRNAs) mediate silencing of transposable elements and thereby protect the genome. New insights are being gained into the formation and functions of piRNAs, and where they exert their action in the cell.

    • Mikiko C. Siomi
    • Kaoru Sato
    • Alexei A. Aravin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 246-258

  • PIWI protein contains arginine rich motifs that are post-translationally modified to symmetrically methylated arginine (sDMA) residues. Here the authors show that piRNA loading into Aub triggers sDMA modification which is recognized by Krimper to promote formation of Krimper-Aub-Ago3 complex for piRNA amplification in Drosophila.

    • Xiawei Huang
    • Hongmiao Hu
    • Sisi Li
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • One of two studies that identifies a new class of small RNAs that interact with one Argonaute subfamily, the Piwi class. These testis-specific small RNAs, called 'piRNAs', are slightly longer than the previously described siRNAs and miRNAs.

    • Alexei Aravin
    • Dimos Gaidatzis
    • Thomas Tuschl
    Research
    Nature
    Volume: 442, P: 203-207

  • Over evolutionary time genes can undergo duplication, and may accumulate mutations that render them non-functional pseudogenes, which are thought to be uninteresting. This study (and that of the group of Sasaki) shows that pseudogenes can in fact influence gene expression.

    • Oliver H. Tam
    • Alexei A. Aravin
    • Gregory J. Hannon
    Research
    Nature
    Volume: 453, P: 534-538

  • In this review, Aravin and colleagues examine bacterial and archaeal Argonaute proteins, discuss their diverse architectures and their possible roles in host defense, proposing additional functions for Argonaute proteins in prokaryotic cells.

    • Lidiya Lisitskaya
    • Alexei A. Aravin
    • Andrey Kulbachinskiy
    ReviewsOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The Microrchidia (Morc) family of GHKL ATPases are important repressors of transposons and other DNA-methylated and silent genes in A. thaliana. Here, the authors show that MORC1 is responsible for repression and methylation of specific classes of transposons in the mouse male germline.

    • William A. Pastor
    • Hume Stroud
    • Steven E. Jacobsen
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-14

  • Argonaute protein from the bacterium C. butyricum targets multicopy genetic elements and functions in the suppression of plasmid and phage propagation, and there appears to be a DNA-mediated immunity pathway in prokaryotes.

    • Anton Kuzmenko
    • Anastasiya Oguienko
    • Andrey Kulbachinskiy
    Research
    Nature
    Volume: 587, P: 632-637

  • Giacomo Cavalli, Frédéric Bantignies and colleagues report the establishment of stable and isogenic Drosophila lines carrying alternative epialleles, defined by different levels of H3K27me3. They show that environmental changes modulate the expressivity of the epialleles and that epilines can be reset to a naive state, thus indicating that the inheritance of this phenotypic variability is epigenetic.

    • Filippo Ciabrelli
    • Federico Comoglio
    • Giacomo Cavalli
    Research
    Nature Genetics
    Volume: 49, P: 876-886

  • RNA interference screens were used to identify chromatin-associated factors that impede reprogramming of somatic cells into iPS cells; suppression of the chromatin assembly factor CAF-1 enhances the generation of iPS cells by rendering chromatin more accessible to pluripotency transcription factors.

    • Sihem Cheloufi
    • Ulrich Elling
    • Konrad Hochedlinger
    Research
    Nature
    Volume: 528, P: 218-224

  • Pachytene Piwi-interacting RNAs (piRNAs) are abundant small non-coding RNAs expressed in mammalian germ lines. A new study indicates that, among the diverse pool of piRNA sequences, a small number act as highly selective guides that induce cleavage of coding and non-coding transcripts, thus promoting piRNA generation and regulating gene expression.

    • Alexei A. Aravin
    News & Views
    Nature Genetics
    Volume: 52, P: 644-645