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Showing 1–2 of 2 results
Advanced filters: Author: Alexei Buevich Clear advanced filters

  • In this study, authors employ fragment-based lead discovery to identify WRN inhibitors. The fragment hits reveal an additional allosteric pocket and uncover a previously uncharacterized structural conformation of the WRN helicase domain with unique orientations of the ATPase domains

    • Rachel L. Palte
    • Mihir Mandal
    • Daniel F. Wyss
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17