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Cell Death & Disease (4)
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Showing 1–20 of 20 results

Advanced filters: Author: Alexei Degterev Clear advanced filters

Addendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev
Zhihong Huang
Junying Yuan
Amendments and Corrections15 Feb 2013
Nature Chemical Biology

Volume: 9, P: 192
ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.

Hayley I. Muendlein
Wilson M. Connolly
Alexander Poltorak
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Correction: Corrigendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev
Zhihong Huang
Junying Yuan
Amendments and Corrections01 Sept 2005
Nature Chemical Biology

Volume: 1, P: 234
Necroptosis blockade prevents lung injury in severe influenza

A newly developed RIPK3 inhibitor blocks necroptosis of lung cells, reduces lung inflammation and prevents mortality in a mouse model of influenza A virus infection.

Avishekh Gautam
David F. Boyd
Siddharth Balachandran
Research10 Apr 2024
Nature

Volume: 628, P: 835-843
Expansion and evolution of cell death programmes

Cell death has historically been divided into regulated (apoptotic) and unregulated (necrotic) mechanisms. Emerging evidence, however, suggests that these two categories do not adequately explain all cell death mechanisms. How and why might non-apoptotic, regulated cell death mechanisms have evolved?

Alexei Degterev
Junying Yuan
Reviews01 May 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 378-390
Is SIRT2 required for necroptosis?

Kim Newton
Joanne M. Hildebrand
John Silke
Research26 Feb 2014
Nature

Volume: 506, P: E4-E6
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-x_L

Alexei Degterev
Alexey Lugovskoy
Junying Yuan
Research17 Jan 2001
Nature Cell Biology

Volume: 3, P: 173-182
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev
Zhihong Huang
Junying Yuan
Research29 May 2005
Nature Chemical Biology

Volume: 1, P: 112-119
Identification of RIP1 kinase as a specific cellular target of necrostatins

Alexei Degterev
Junichi Hitomi
Junying Yuan
Research13 Apr 2008
Nature Chemical Biology

Volume: 4, P: 313-321
An atlas of substrate specificities for the human serine/threonine kinome

Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by negative selectivity

Jared L. Johnson
Tomer M. Yaron
Lewis C. Cantley
ResearchOpen Access11 Jan 2023
Nature

Volume: 613, P: 759-766
Phenytoin inhibits necroptosis

Anne von Mässenhausen
Wulf Tonnus
Andreas Linkermann
ResearchOpen Access02 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-15
A new savior for neurons

Alexei Degterev
Junying Yuan
News & Views01 Nov 1999
Nature Neuroscience

Volume: 2, P: 930-932
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154
Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

Limin Wu
Joon Yong Chung
Michael J. Whalen
ResearchOpen Access09 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-16
Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom Delanghe
Jon Huyghe
Mathieu J. M. Bertrand
ResearchOpen Access14 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-13
Correction to: Phenytoin inhibits necroptosis

Anne von Mässenhausen
Wulf Tonnus
Andreas Linkermann
Amendments and CorrectionsOpen Access24 May 2018
Cell Death & Disease

Volume: 9, P: 1
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Inhibition of cell migration by PITENINs: the role of ARF6

B Miao
I Skidan
A Degterev
Research19 Dec 2011
Oncogene

Volume: 31, P: 4317-4332
A decade of caspases

Alexei Degterev
Michael Boyce
Junying Yuan
Reviews24 Nov 2003
Oncogene

Volume: 22, P: 8543-8567
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2