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Showing 1–4 of 4 results
Advanced filters: Author: Alexei F. Kirkin Clear advanced filters

  • Tumour heterogeneity and off-target toxicity are current challenges of cancer immunotherapy. Karine Dzhandzhugazyan, Per Guldberg and Alexei Kirkin discuss how epigenetic induction of tumour antigens in antigen-presenting cells may form the basis for multi-target therapies.

    • Karine N. Dzhandzhugazyan
    • Per Guldberg
    • Alexei F. Kirkin
    Special Features
    Nature Materials
    Volume: 17, P: 475-477

  • A critical determinant of tumor eradication by adoptive immunotherapy is the tumor associated antigen recognized by cytotoxic T lymphocytes. Here the authors generate ex vivo autologous cytotoxic T lymphocytes by exposure to antigens induced by DNA demethylation and report the results of a phase 1 trial of 25 patients with recurrent glioblastoma multiforme with tumor regression in three patients.

    • Alexei F. Kirkin
    • Karine N. Dzhandzhugazyan
    • Walter Fischer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12