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Showing 1–3 of 3 results
Advanced filters: Author: Alexei Gorelik Clear advanced filters

  • Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight into its mechanism of action.

    • Ahmad Gebai
    • Alexei Gorelik
    • Bhushan Nagar
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid sphingomyelinase function and regulation.

    • Alexei Gorelik
    • Katalin Illes
    • Bhushan Nagar
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9