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Showing 1–5 of 5 results
Advanced filters: Author: Alexei V. Korennykh Clear advanced filters

  • Accumulation of misfolded proteins results in the activation of the unfolded protein response (UPR) in the endoplasmic reticulum. Ire1 is important in this pathway and functions as a kinase and endoribonuclease. This paper solves the crystal structure of Ire1 kinase and shows that it undergoes spontaneous assembly into a rod-shaped oligomer. This arrangement positions the kinase domains for trans-autophosphorylation, orders the RNase domains and creates an interaction site for mRNA substrate binding.

    • Alexei V. Korennykh
    • Pascal F. Egea
    • Peter Walter
    Research
    Nature
    Volume: 457, P: 687-693

  • It is shown that after activation, Ire1 molecules cluster into discrete foci containing high order oligomers on the endoplasmic reticulum membrane. HAC1 mRNA is recruited to these foci by means of a sequence in its 3′ UTR and is processes at these sites. Disruption of either Ire1 clustering or HAC1 mRNA recruitment impairs UPR signalling. Hence HAC1 mRNA is delivered to a site where it is processed thus ensuring that it is only translated when UPR is on.

    • Tomás Aragón
    • Eelco van Anken
    • Peter Walter
    Research
    Nature
    Volume: 457, P: 736-740

  • Bacteria in the human gut and oral microbiome encode enzymes that selectively phosphorylate the antidiabetic drug acarbose—an inhibitor of both human and bacterial α-glucosidases—resulting in its inactivation and limiting the drug's effects on the ability of the host to metabolize complex carbohydrates.

    • Jared Balaich
    • Michael Estrella
    • Mohamed S. Donia
    Research
    Nature
    Volume: 600, P: 110-115

  • Nocturnin is a rhythmically expressed protein that regulates metabolism under the control of circadian clock proposed to function through the deadenylation of metabolic enzyme mRNAs. Here the authors show that Nocturnin and its fly homolog Curled catalyze the removal of 2′-phosphate from NADP+ and NADPH, providing a direct link to metabolic regulation.

    • Michael A. Estrella
    • Jin Du
    • Alexei Korennykh
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10