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Showing 1–21 of 21 results
Advanced filters: Author: Alexey Alekseev Clear advanced filters

  • Genome-wide sequencing of 180 ancient individuals shows a continuous gradient of ancestry in Early-to-Mid-Holocene hunter-gatherers from the Baltic to the Transbaikal region and distinct contemporaneous groups in Northeast Siberia, and provides insights into the origins of modern Uralic and Yeniseian speakers.

    • Tian Chen Zeng
    • Leonid A. Vyazov
    • David Reich
    Research
    Nature
    Volume: 644, P: 122-132

  • A Dirac plasma in high-mobility graphene shows anomalous magnetotransport and giant magnetoresistance that reaches more than 100 per cent in a low magnetic field at room temperature.

    • Na Xin
    • James Lourembam
    • Alexey I. Berdyugin
    ResearchOpen Access
    Nature
    Volume: 616, P: 270-274

  • Nucleocytoplasmic Large DNA Viruses (NCLDV) that infect algae encode two distinct families of microbial rhodopsins. Here, the authors characterise two proteins form the viral rhodopsin group 1 OLPVR1 and VirChR1, present the 1.4 Å crystal structure of OLPVR1 and show that viral rhodopsins 1 are light-gated cation channels.

    • Dmitrii Zabelskii
    • Alexey Alekseev
    • Valentin Gordeliy
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Using structural, functional and spectroscopic investigations of a bacterial inward proton-pumping rhodopsin, Kovalev et al. reveal its molecular mechanism and show how proton wires mediate ion selectivity and direct proton transport through cell membrane.

    • Kirill Kovalev
    • Fedor Tsybrov
    • Valentin Gordeliy
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 970-979

  • Rhodopsins are ubiquitous light-driven membrane proteins that have diverse functions in nature, and value as optogenetics tools. Here the authors characterise type 1 viral channelrhodopsins, showing that they regulate intracellular calcium and can be used for the photocontrol of muscle contraction in vivo.

    • Ana-Sofia Eria-Oliveira
    • Mathilde Folacci
    • Michel Vivaudou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Light-driven sodium-pumping rhodopsins are unique ion transporters. Here, authors present a characterization of such rhodopsins with a modified active center allowing for efficient sodium transport under various environmental conditions.

    • E. Podoliak
    • G. H. U. Lamm
    • K. Kovalev
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The Na+-pumping KR2 rhodopsin from Krokinobacter eikastus is a light-driven non-proton cation pump whose mechanism of pumping remains to be understood. Here authors solved crystal structures of the O-intermediate state of the pentameric form of KR2 and its D116N and H30A mutants, which sheds light on the mechanism of non-proton cation light-driven pumping.

    • Kirill Kovalev
    • Roman Astashkin
    • Valentin Gordeliy
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Rhodopsin genes have been identified in some large double-stranded DNA viruses, but the structure and functions of viral rhodopsins remain unknown. Here authors present crystal structure and characterization of an Organic Lake Phycodnavirus rhodopsin II (OLPVRII) which forms a pentamer and is a weak proton pump.

    • Dmitry Bratanov
    • Kirill Kovalev
    • Valentin Gordeliy
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Crystal structures of the microbial rhodopsin KR2, a recently discovered light-driven sodium pump, reveal the translocation pathway of sodium ions and shed light on the molecular mechanism of ion pumping.

    • Ivan Gushchin
    • Vitaly Shevchenko
    • Valentin Gordeliy
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 390-395

  • Proteorhodopsins act as light-driven outward proton pumps mainly at neutral and alkaline pH, however, mirror proteorhodopsins are known to operate only at acidic pH. Here, the authors report the detailed structural and functional characterization of pH mirror proteorhodopsin SpaR as well as its diverse biological roles.

    • Ivan S. Okhrimenko
    • Kirill Kovalev
    • Valentin I. Gordeliy
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-16

  • Zabelskii et al. present a structural and functional analysis of the lightdriven proton pump LR (Mac) from the fungus Leptosphaeria maculans. Their findings indicate that the archaeal ancestry of eukaryotic type 1 rhodopsins, and that the archaeal host of the proto-mitochondrial endosymbiont was capable of light-driven proton pumping.

    • Dmitrii Zabelskii
    • Natalia Dmitrieva
    • Valentin Gordeliy
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12

  • Amphiphilic thermoresponsive copolymer bottlebrushes based on methoxy oligo(ethylene glycol) methacrylate (MOEGM) and alkoxy(C12-C14) oligo(ethylene glycol) methacrylate (DOEGM) have been synthesized via RAFT and conventional free-radical polymerization in toluene. In water, these copolymer brushes form flower-like micelles with a hydrophobic core consisting of a polymer backbone and alkyl(C12–C14) groups and poly(ethylene glycol) linear chains and loops forming a hydrophilic shell. The size and aggregation number of the micelles depend on the copolymer composition and chain length, as well as on the synthesis method.

    • Alexey Р. Sivokhin
    • Dmitry V. Orekhov
    • Sergey D. Zaitsev
    Research
    Polymer Journal
    Volume: 53, P: 655-665