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Showing 1–7 of 7 results
Advanced filters: Author: Alexey Ruzov Clear advanced filters

  • R-loops contain DNA:RNA hybrids and an unpaired single-stranded DNA. N6-methyladenosine (m6A) has been reported to modulate R-loop levels, but with varying outcomes (R-loop resolution versus stabilization). We propose that in different contexts, m6A may either directly prevent R-loop accumulation or stabilize R-loops via the formation of RNA abasic sites.

    • Abdulkadir Abakir
    • Alexey Ruzov
    Comments & Opinion
    Nature Genetics
    Volume: 56, P: 1995-1998

  • R-loops—nucleic acid structures composed of an RNA:DNA hybrid and displaced single-stranded DNA—are abundant in the genome and may impair progression of the replication fork, thus leading to accumulation of DNA damage and genome instability. A new study demonstrates that SWI/SNF chromatin-remodeling complexes are instrumental in resolving such R-loop-mediated transcription–replication conflicts, highlighting the importance of these chromatin remodelers in R-loop homeostasis and the maintenance of genome integrity.

    • Abdulkadir Abakir
    • Alexey Ruzov
    News & Views
    Nature Genetics
    Volume: 53, P: 940-941

  • Transposable elements are genetic parasites that have colonised genomes and they express as parts of coding and noncoding RNAs. Here, the authors explore how they are expressed in transcripts in normal human development, and how they alter transcript dynamics.

    • Isaac A. Babarinde
    • Xiuling Fu
    • Andrew P. Hutchins
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24

  • N6-methyladenosine (m6A) is prevalent at RNA:DNA hybrids in human pluripotent stem cells. The m6A reader YTHDF2 interacts with R-loop-enriched loci in dividing cells, and YTHDF2 loss leads to increased R-loop levels and accumulation of γH2AX.

    • Abdulkadir Abakir
    • Tom C. Giles
    • Alexey Ruzov
    Research
    Nature Genetics
    Volume: 52, P: 48-55

  • Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturation, suggesting a link between 5cac and LINE-1 activity.

    • Martin J. Blythe
    • Ayhan Kocer
    • Alexey Ruzov
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11