A Ketogenic Diet (KD) that improves memory in aged C57BL/6 mice is tested in APP/PS1 Alzheimer’s mice. Seven months KD rescues Long-Term-Potentiation to wild-type levels, as does a one-hour soak with 3 mM Betahydroxybutyrate. KD increases synaptic pathways but does not alter Aβ amyloid.
- Jacopo Di Lucente
- Giuseppe Persico
- Gino A. Cortopassi
