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Showing 1–2 of 2 results
Advanced filters: Author: Alexey V. Yaremenko Clear advanced filters

  • Intravenous interleukin-10 messenger RNA nanoparticles enhance immune responses in preclinical tumour models, promoting T cell activity and dendritic cell maturation, as well as improving survival and tumour eradication rates, with limited interleukin-10-induced systemic toxicity.

    • Chuang Liu
    • Xiangang Huang
    • Wei Tao
    Research
    Nature Nanotechnology
    Volume: 20, P: 1526-1538

  • mRNA technologies offer potential solutions for HIV-1 vaccine development by enabling rapid, safe and modular antigen design that can initiate rare antibody lineages required for broad protection. In this Review, we discuss preclinical and early clinical evidence, outline remaining challenges — particularly breadth and durability — and discuss delivery and manufacturing advances that may help translate these approaches into effective preventive and therapeutic strategies.

    • Chuang Liu
    • Alexey V. Yaremenko
    • Wei Tao
    Reviews
    Nature Reviews Bioengineering
    P: 1-19