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Showing 1–11 of 11 results
Advanced filters: Author: Alexi Nott Clear advanced filters

  • With evidence from model organisms and human population genetic analysis, two studies in this issue report discoveries that eukaryotic Top3β has RNA topoisomerase activity and, in a ribonucleoprotein complex with FMRP, is important for neurodevelopment and normal cognition.

    • Alexi Nott
    • Li-Huei Tsai
    News & Views
    Nature Neuroscience
    Volume: 16, P: 1163-1164

  • Cleavage Under Targets & Tagmentation is a rapidly expanding technique, but thorough evaluation and benchmarking against established ChIP-seq datasets are required. This study shows that CUT&Tag recovers ~54% of ENCODE peaks for H3K27ac/H3K27me3 in K562 cells, with CUT&Tag peaks mapping to key cell type-specific regulatory regions.

    • Leyla Abbasova
    • Paulina Urbanaviciute
    • Sarah J. Marzi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The brain’s resident immune cells retain a long-lasting memory of peripheral inflammation. This memory can influence the response to stroke and the progression of Alzheimer’s disease in mouse models.

    • Alexi Nott
    • Christopher K. Glass
    News & Views
    Nature
    Volume: 556, P: 312-313

  • Alzheimer’s disease is a complex, heterogeneous disorder with multiple genetic subtypes. Spatial and single-cell gene expression analyses of these subtypes have provided new insights into general and subtype-specific cellular and molecular mechanisms of Alzheimer’s disease.

    • Alexi Nott
    • Inge R. Holtman
    News & Views
    Nature Genetics
    Volume: 56, P: 2592-2593

  • This protocol describes procedures for isolation of nuclei of multiple cell populations (neurons, microglia, oligodendrocytes, and astrocytes) from resected or postmortem brain tissue that are compatible with downstream epigenomic or transcriptomic profiling.

    • Alexi Nott
    • Johannes C. M. Schlachetzki
    • Christopher K. Glass
    Protocols
    Nature Protocols
    Volume: 16, P: 1629-1646

  • De novo mutations in CHD8 are associated with autism spectrum disorder, but the basic biology of CHD8 remains poorly understood. Here the authors find that Chd8 knockdown during cortical development results in defective neural progenitor proliferation and differentiation that ultimately manifests in abnormal neuronal morphology and behaviors in adult mice.

    • Omer Durak
    • Fan Gao
    • Li-Huei Tsai
    Research
    Nature Neuroscience
    Volume: 19, P: 1477-1488

  • Mutations in MECP2 cause Rett syndrome. The authors show that a MeCP2-HDAC3 complex positively regulates a subset of neuronal genes through FOXO recruitment and deacetylation, and that HDAC3 loss contributes to cognitive and social deficits in mice. Rett-patient-derived cells exhibited similar HDAC3-FOXO-mediated transcriptional impairments and were rescued by gene editing.

    • Alexi Nott
    • Jemmie Cheng
    • Li-Huei Tsai
    Research
    Nature Neuroscience
    Volume: 19, P: 1497-1505