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Showing 1–4 of 4 results
Advanced filters: Author: Alexis B. Cortot Clear advanced filters

  • The emergence of resistant subpopulations often underlies the development of resistance to cancer therapy. Here, using a DNA barcoding approach, the authors demonstrate EGFR TKI treatment in non-small cell lung cancer enriches for resistant subpopulation which can be prevented by treatment with the multikinase inhibitor sorafenib via inhibition of MKNK, STAT3 and MCL1.

    • Lisa Brunet
    • David Alexandre
    • Luca Grumolato
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Non-small-cell lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) often show a clinical response to EGFR kinase inhibitors but tend to develop drug-resistance mutations, including the gatekeeper T790M mutation. Here, a new class of EGFR inhibitors is developed; these agents are 30- to 100-fold more potent against EGFR with the T790M mutation, and up to 100-fold less potent against wild-type EGFR, than current EGFR inhibitors.

    • Wenjun Zhou
    • Dalia Ercan
    • Pasi A. Jänne
    Research
    Nature
    Volume: 462, P: 1070-1074