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Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

Vivek Swarup
Flora I. Hinz
Daniel H. Geschwind
Research03 Dec 2018
Nature Medicine

Volume: 25, P: 152-164
Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

Olfaction in mammals relies on a toolbox composed of a varied set of sensory neurons. Here, the authors report in mice that this olfactory neuronal diversity relies both on the chemoreceptor that each neuron expresses and on the experience of this neuron.

Luis Flores Horgue
Alexis Assens
Ivan Rodriguez
ResearchOpen Access25 May 2022
Nature Communications

Volume: 13, P: 1-16
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

T cell responses can be generated to either pathogen infection or from priming with a vaccine. Here the authors compare T cell generation, phenotype and single cell transcriptome of participants vaccinated with a mpox vaccine or infected with the virus showing that the virus induced T cells showed more effective function and phenotype.

Ji-Li Chen
Beibei Wang
Tao Dong
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-17
Efficient long-range conduction in cable bacteria through nickel protein wires

Filamentous cable bacteria conduct electrical currents over centimeter distances through fibers embedded in their cell envelope. Here, Boschker et al. show that the fibers consist of a conductive core containing nickel proteins that is surrounded by an insulating protein shell.

Henricus T. S. Boschker
Perran L. M. Cook
Filip J. R. Meysman
ResearchOpen Access28 Jun 2021
Nature Communications

Volume: 12, P: 1-12
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

The myeloma cell surface proteome regulates plasma cell biology and delineates therapy targets. Here, the authors profile the myeloma surfaceome at baseline and in drug resistance, finding the potential target CCR10, and include a streamlined approach to primary sample analysis.

Ian D. Ferguson
Bonell Patiño-Escobar
Arun P. Wiita
ResearchOpen Access15 Jul 2022
Nature Communications

Volume: 13, P: 1-17
Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung

Tracing barcoded clones of Klebsiella pneumoniae during pneumonia with bacteremia, Holmes and colleagues identify two modes of dissemination, with high or low bacterial burdens, and define the host and bacterial factors that influence this process.

Caitlyn L. Holmes
Katherine G. Dailey
Michael A. Bachman
ResearchOpen Access17 Jan 2025
Nature Communications

Volume: 16, P: 1-13
A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

Cross-talk between innate immune cells helps to enhance the antitumor T cell response during checkpoint blockade therapy.

Kevin C. Barry
Joy Hsu
Matthew F. Krummel
Research25 Jun 2018
Nature Medicine

Volume: 24, P: 1178-1191
Mechanically-primed voltage-gated proton channels from angiosperm plants

The authors describe a proton channel protein in the vasculature of Arabidopsis thaliana that requires both mechanical and electrical stimuli to turn on. A mechanistic analysis identifies the molecular determinants for the hybrid activation process.

Chang Zhao
Parker D. Webster
Francesco Tombola
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Murine breast cancers disorganize the liver transcriptome in a zonated manner

Spatial transcriptomics reveal how distant cancer affect gene expression and zonation in mouse liver in a manner that differs between biological pathways.

Alexis Vandenbon
Rin Mizuno
Shinpei Kawaoka
ResearchOpen Access24 Jan 2023
Communications Biology

Volume: 6, P: 1-12
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Author Correction: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Naomi Wilcox
Martine Dumont
Jacques Simard
Amendments and CorrectionsOpen Access26 Sept 2023
Nature Genetics

Volume: 55, P: 2009
Mock community experiments can inform on the reliability of eDNA metabarcoding data: a case study on marine phytoplankton

Nadia Marinchel
Alexis Marchesini
Antonella Penna
ResearchOpen Access17 Nov 2023
Scientific Reports

Volume: 13, P: 1-15
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Prevalence and architecture of de novo mutations in developmental disorders

Whole-exome analysis of individuals with developmental disorders shows that de novo mutations can equally cause loss or altered protein function, but that most mutations causing altered protein function have not yet been described.

Jeremy F. McRae
Stephen Clayton
Matthew E. Hurles
Research25 Jan 2017
Nature

Volume: 542, P: 433-438
Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons

Mark van den Hurk
Shong Lau
Cedric Bardy
ResearchOpen Access18 Oct 2022
npj Parkinson's Disease

Volume: 8, P: 1-18
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Meta-analysis of three large whole-exome sequencing datasets highlights protein-truncating and rare missense variants associated with breast cancer susceptibility.

Naomi Wilcox
Martine Dumont
Jacques Simard
ResearchOpen Access17 Aug 2023
Nature Genetics

Volume: 55, P: 1435-1439
Genetic and immunologic features of recurrent stage I lung adenocarcinoma

Johannes R. Kratz
Jack Z. Li
David M. Jablons
ResearchOpen Access08 Dec 2021
Scientific Reports

Volume: 11, P: 1-16
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Genome-scale data reveal the role of hybridization in lichen-forming fungi

Rachel Keuler
Alexis Garretson
Steven D. Leavitt
ResearchOpen Access30 Jan 2020
Scientific Reports

Volume: 10, P: 1-14
Global genetic capacity for mixotrophy in marine picocyanobacteria

Alexis P Yelton
Silvia G Acinas
Sallie W Chisholm
Research03 May 2016
The ISME Journal

Volume: 10, P: 2946-2957
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4

Search

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

Efficient long-range conduction in cable bacteria through nickel protein wires

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

Mechanically-primed voltage-gated proton channels from angiosperm plants

Murine breast cancers disorganize the liver transcriptome in a zonated manner

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Author Correction: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Mock community experiments can inform on the reliability of eDNA metabarcoding data: a case study on marine phytoplankton

CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Prevalence and architecture of de novo mutations in developmental disorders

Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons

Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Genetic and immunologic features of recurrent stage I lung adenocarcinoma

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Genome-scale data reveal the role of hybridization in lichen-forming fungi

Global genetic capacity for mixotrophy in marine picocyanobacteria

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

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