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Showing 1–2 of 2 results
Advanced filters: Author: Algera Goga Clear advanced filters

  • Homeostasis of the intestinal epithelium is crucial for the maintenance of the epithelial barrier. Here, the authors show that mir-802 ablation in the mouse intestine impairs enterocyte differentiation and glucose absorption, enhances Paneth cell function by increasing Tmed9-mediated defensin secretion, and increases epithelial cell turnover.

    • Algera Goga
    • Büsra Yagabasan
    • Markus Stoffel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Advances in oligonucleotide design and delivery platforms have enabled the recent approval of several oligonucleotide-based therapies. Here, Goga and Stoffel discuss applications of RNA-silencing oligonucleotide therapeutics in metabolic diseases, recent developments in the field, ongoing challenges and possible future directions.

    • Algera Goga
    • Markus Stoffel
    Reviews
    Nature Reviews Drug Discovery
    Volume: 21, P: 417-439