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Showing 1–3 of 3 results
Advanced filters: Author: Ali Nikoomanzar Clear advanced filters
  • Next-generation sequencing technologies vary in performance, which is often measured by metrics such as sequencing speed, accuracy and read length. Here, the authors present a new sequencing by synthesis method that monitors polymerase binding to DNA, and suggest that this method has the potential to generate longer and faster reads.

    • Michael John Robert Previte
    • Chunhong Zhou
    • Molly Min He
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12
  • Artificial genetic polymers (XNAs) have been explored for their nuclease activity, but XNAzymes have proven challenging to discover by in vitro selection. Here, the authors generate an efficient RNA-cleaving 2’-fluoroarabino nucleic acid enzyme (FANAzyme) by in vitro evolution using natural DNA polymerases.

    • Yajun Wang
    • Arlene K. Ngor
    • John C. Chaput
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10
  • The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerases for synthetic genetics applications.

    • Nicholas Chim
    • Changhua Shi
    • John C. Chaput
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11