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Advanced filters: Author: Ali Zamat Clear advanced filters

Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens

Gamboa et al. develop a chimeric antigen receptor (CAR) T cell therapeutic strategy based on synthetic antigens that are delivered to the tumor by lipid nanoparticles and demonstrate the therapeutic efficacy of their approach using CAR T cells directed against the synthetic antigen.

Lena Gamboa
Ali H. Zamat
Gabriel A. Kwong
Research16 May 2025
Nature Cancer

Volume: 6, P: 1073-1087
Tumour priming by ultrasound mechanogenetics for CAR T therapy

A focused-ultrasound-mediated mechanogenetics approach enables the genetic modification of cancer cells near solid tumours to activate chimeric antigen receptor T cell response and achieve tumour suppression at distinct sites.

Chi Woo Yoon
Chunyang Song
Yingxiao Wang
ResearchOpen Access31 Oct 2025
Nature Materials

P: 1-12
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control

Spatial control of the production of immunomodulatory biologics by CAR T cells engineered with synthetic gene switches that respond to mild elevations in temperature enhances the cells’ antitumour activity.

Ian C. Miller
Ali Zamat
Gabriel A. Kwong
Research12 Aug 2021
Nature Biomedical Engineering

Volume: 5, P: 1348-1359