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Showing 1–2 of 2 results
Advanced filters: Author: Alice Lallo Clear advanced filters

  • Cancer patients often respond well to primary treatment but then develop resistance. Here, Misale et al. show that dual treatment with EGFR and MEK inhibitors block resistance in mice containing patient-derived xenografts and provide a mathematical model that describes the temporal development of resistant tumour clones.

    • Sandra Misale
    • Ivana Bozic
    • Alberto Bardelli
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models reveal a mechanism of drug resistance in SCLC mediated by Notch and nitric oxide activation of soluble guanylate cyclase signalling.

    • Maximilian W. Schenk
    • Sam Humphrey
    • Kristopher K. Frese
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15