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Showing 1–2 of 2 results
Advanced filters: Author: Alice Lepelley Clear advanced filters

  • Mutations in LSM11 and RNU7-1, which encode components of the replication-dependent histone pre-mRNA–processing complex, cause an autoinflammatory syndrome due to enhanced interferon signaling mediated by the cGAS–STING pathway, showing an essential role for nuclear histones in suppressing the immunogenicity of self-DNA.

    • Carolina Uggenti
    • Alice Lepelley
    • Yanick J. Crow
    Research
    Nature Genetics
    Volume: 52, P: 1364-1372

  • Self-derived DNA may trigger interferon-driven autoinflammation mediated by the cGAS-STING axis. Here, the authors find that mutations in the GTPase ARF1 cause an interferonopathy by promoting aberrant mitochondrial DNA release and impairing STING recycling.

    • Maximilian Hirschenberger
    • Alice Lepelley
    • Konstantin M. J. Sparrer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20